UFC Fight Night: Smith vs. Spann
| Sport: | MMA |
| Promotion: | UFC |
| Date: | Sept. 18, 2021 |
| Venue: | UFC Apex |
| City: | Enterprise, Nevada |
| Broadcast: | ESPN |
Main Event
Light Heavyweight Anthony Smith vs. Ryan Spann
Main Card
Women's Flyweight Ariane Lipski vs. Mandy Bohm